tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 (ROR1, NTRKR1)

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Function

Structure

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

  • expressed strongly in human heart, lung, & kidney, but weakly in the CNS
  • expressed at high levels during early embryonic development
  • expression levels drop strongly around day 16 & there are only very low levels in adult tissues
  • short isoform is strongly expressed in fetal & adult CNS & in a variety of human cancers, including those originating from CNS or PNS neuroectoderm

Pathology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q01973.html
  2. 2.0 2.1 Cui B, Zhang S, Chen L et al Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis. Cancer Res. 2013 Jun 15;73(12):3649-60 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23771907
  3. Hojjat-Farsangi M, Ghaemimanesh F, Daneshmanesh AH et al Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells. PLoS One. 2013 Apr 8;8(4):e61167 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23593420
  4. Rebagay G, Yan S, Liu C, Cheung NK. ROR1 and ROR2 in human malignancies: potentials for targeted therapy. Front Oncol. 2012;2:34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22655270
  5. Zhang S, Chen L, Cui B, Chuang HY et al ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012;7(3):e31127 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22403610

Database