tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 (ROR1, NTRKR1)
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Function
- tyrosine-protein kinase receptor
- orphan receptor
- function not well understood
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, ROR subfamily
- contains 1 FZ (frizzled) domain
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 kringle domain
- contains 1 protein kinase domain
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- expressed strongly in human heart, lung, & kidney, but weakly in the CNS
- expressed at high levels during early embryonic development
- expression levels drop strongly around day 16 & there are only very low levels in adult tissues
- short isoform is strongly expressed in fetal & adult CNS & in a variety of human cancers, including those originating from CNS or PNS neuroectoderm
Pathology
- upregulated with metastases[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q01973.html
- ↑ 2.0 2.1 Cui B, Zhang S, Chen L et al Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis. Cancer Res. 2013 Jun 15;73(12):3649-60 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23771907
- ↑ Hojjat-Farsangi M, Ghaemimanesh F, Daneshmanesh AH et al Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells. PLoS One. 2013 Apr 8;8(4):e61167 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23593420
- ↑ Rebagay G, Yan S, Liu C, Cheung NK. ROR1 and ROR2 in human malignancies: potentials for targeted therapy. Front Oncol. 2012;2:34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22655270
- ↑ Zhang S, Chen L, Cui B, Chuang HY et al ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012;7(3):e31127 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22403610