tyrosine-protein kinase receptor UFO; AXL proto-oncogene protein (AXL, UFO)
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Function
- may function as a signal transducer between specific cell types of mesodermal origin
- heterodimer & heterotetramer with GAS6
- receptor tyrosine kinase
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily
- contains 2 fibronectin F3 modules
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 protein kinase domain
Compartment
membrane
Alternative splicing
named isoforms=2
Pathology
- in case of filovirus infection, seems to function as a cell entry factor
- has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia
- originally identified as a tyrosine kinase encoded by a transforming gene from primary human myeloid leukemia cells
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P30530.html
- ↑ Varnum BC et al Axl receptor tyrosine kinase stimulated by the vitamin K- dependent protein encoded by growth-arrest-specific gene 6. Nature 373:623 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7854420