growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand (GAS6, AXLLG)

Function

• ligand for tyrosine-protein kinase receptors AXL, TYRO3 & MER
• implicated in cell growth & survival, cell-cell adhesion & cell migration
• role in thrombosis by amplifying platelet aggregation & secretion
• role in endothelial cell survival during acidification by preventing apoptosis
• role in optimal cytokine signaling during human natural killer cell development
• role in hepatic regeneration
• role in gonadotropin-releasing hormone neuron survival & migration
• isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kD protein & a C-terminal 50 kD protein including the laminin G-like domains which activates AXL
• gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation
  • these residues are essential for binding of Ca+2 (putative)
• heterodimer & heterotetramer with AXL

Structure

• contains 4 EGF-like domains
• contains 1 Gla (gamma-carboxy-glutamate) domain
• contains 2 laminin G-like domains
• Gas6 has significant homology with protein S

Compartment

secreted

Alternative splicing

named isoforms=3

Expression

• plasma
• isoform 1 & isoform 2 are widely expressed
• isoform 1 is the predominant form in spleen

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2621
• OMIM: https://mirror.omim.org/entry/600441
• UniProt: http://www.uniprot.org/uniprot/Q14393.html