epithelial discoidin domain-containing receptor 1; epithelial discoidin domain receptor 1; tyrosine kinase DDR; discoidin receptor tyrosine kinase; tyrosine-protein kinase CAK; cell adhesion kinase; TRK E; protein-tyrosine kinase RTK 6; HGK2; CD167 antigen-like family member A; CD167a (DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE)

Function

• may be involved in cell-cell interactions & recognition

Structure

• Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates
• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 1 F5/8 type C domain
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed at low levels in most adult tissues
• highest expression in the brain & lung

Pathology

• abundant in breast carcinoma cell lines

More general terms

• tyrosine kinase receptor (RTK)
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:780
• OMIM: https://mirror.omim.org/entry/600408
• UniProt: http://www.uniprot.org/uniprot/Q08345.html