Leukocyte tyrosine kinase receptor; protein tyrosine kinase 1 (LTK, TYK1)
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Function
- function unknown
- probably a receptor with tyrosine kinase activity
- may receptor for a pre-B lymphocyte growth or differentiation factor
Structure
- belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
- contains 1 protein kinase domain
Compartment
membrane
Alternative splicing
named isoforms=4 Additional isoforms seem to exist
Expression
- expressed in non-hematopoietic cell lines & T-cell & B-cell lines
Comparative biology
- mouse protein may lack an extracellular domain [2]
- mouse mRNA contains non AUG translation initiator
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P29376.html
- ↑ 2.0 2.1 Bernards A, de la Monte SM. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 1990 Jul;9(7):2279-87. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2357970