insulin receptor-related protein; IR-related receptor; contains: insulin receptor-related protein alpha chain & insulin receptor-related protein beta chain (INSRR, IRR)

Function

• probably binds an insulin related protein
• has a tyrosine-protein kinase activity
• phosphorylates insulin receptor substrates IRS-1 & IRS-2

Structure

• probable tetramer of 2 alpha & 2 beta chains linked by disulfide bonds
• the alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain
• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 4 fibronectin F3 modules
• contains 1 protein kinase domain

Compartment

membrane

More general terms

• tyrosine kinase receptor (RTK)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3645
• OMIM: https://mirror.omim.org/entry/147671
• UniProt: http://www.uniprot.org/uniprot/P14616.html