tyrosine-protein kinase ITK/TSK; T-cell-specific kinase; tyrosine-protein kinase Lyk; kinase EMT (ITK, EMT, LYK)

Function

• plays a role in T-cell proliferation & differentiation

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily
• contains 1 Btk-type Zn+2 finger
• contains 1 PH domain
• contains 1 protein kinase domain
• contains 1 SH2 domain
• contains 1 SH3 domain

Compartment

• cell membrane (putative)
• localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells (putative)

Expression

• T-cell lines & natural killer cell lines
• induced by interleukin-2

More general terms

• tyrosine kinase receptor (RTK)
• zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3702
• OMIM: https://mirror.omim.org/entry/186973
• UniProt: http://www.uniprot.org/uniprot/Q08881.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3702