voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)

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Function

forms a channel through the mitochondrial outer membrane & also the plasma membrane
the channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules
in the plasma membrane it is involved in cell volume regulation & apoptosis.
it adopts an open conformation at low or zero membrane potential & a closed conformation at potentials > 30-40 mV
the open state has a weak anion selectivity
the closed state is cation-selective
in association with ANT (inner mitochondrial membrane), may form the permeability transition pore complex (PTPC)
VDAC-1 may serve as the mitochondrial binding site for:
closure of the VDAC-1 channel is the earliest observed mitochondrial change during apoptosis, blocking passage of ADP/ATP
it is thought that bcl-2 may stabilize the open conformation of VDAC-1
interacts with hexokinases (putative)
interacts with BCL2L1
interacts with influenza A virus PB1-F2 protein

consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands
the helical N-terminus folds back into the pore opening & plays a role in voltage-gated channel activity
belongs to the eukaryotic mitochondrial porin family

↑ UniProt http://www.uniprot.org/uniprot/P21796.html
↑ Benz R. Biophysical properties of porin pores from mitochondrial outer membrane of eukaryotic cells. Experientia. 1990 Feb 15;46(2):131-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1689250
↑ Dermietzel R, Hwang TK, Buettner R, Hofer A, Dotzler E, Kremer M, Deutzmann R, Thinnes FP, Fishman GI, Spray DC, et al. Cloning and in situ localization of a brain-derived porin that constitutes a large-conductance anion channel in astrocytic plasma membranes. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):499-503. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7507248
↑ Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11165519