mitochondrial permeability transition pore complex (PTPC)

Function

• voltage-dependent channel across:
  • inner mitochondrial membrane
  • outer mitochondrial membrane
• the open channel allows passage of molecules up to 15000 daltons, including
  • cytochrome C, a key mediator of apoptosis
  • adenine nucleotides (ATP, ADP) through the outer mitochondrial membrane
• both components (VDAC-1 & ANT) are voltage-gated.
• opening of ANT dissipates the H+ gradient across the inner mitochondrial membrane, uncoupling oxidative phosphorylation.

Structure

• components include:
  • VDAC-1 (outer mitochondrial membrane)
  • ANT (inner mitochondrial membrane)

More general terms

• biochemistry

Additional terms

• ADP/ATP translocase, adenine nucleotide translocase (ANT) or ADP/ATP carrier protein
• voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)