band 3 anion transport protein; anion exchange protein 1; anion exchanger 1; AE 1; solute carrier family 4 member 1; CD233 (SLC4A1, AE1, DI, EPB3)
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Introduction
Band # from SDS gel of erythrocyte ghosts.
Function
- Cl-/HCO3- exchange
- the major integral glycoprotein of the erythrocyte membrane
- two functional domains
- integral domain mediates a 1:1 exchange of inorganic anions across the membrane, i.e.
- cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, & hemoglobin
- phosphorylated on Tyr-8 & Tyr-21 most likely by SYK
- PP1- resistant phosphorylation that precedes Tyr-359 & Tyr-904 phosphorylation
- phosphorylated on Tyr-359 & Tyr-904 most likely by LYN
- PP1-inhibited phosphorylation that follows Tyr-8 & Tyr-21 phosphorylation
- phenyl isothiocyanate inhibits anion transport in vitro
Structure
- a dimer in solution
- spans the membrane asymmetrically
- appears to be tetrameric
- belongs to the anion exchanger (TC 2.A.31) family
Compartment
membrane
Expression
Pathology
- defects in SLC4A1 are the cause of:
- defects in SLC4A1 are a cause of
Polymorphism
- SLC4A1 is responsible for 3 blood groups
Laboratory
More general terms
- anion exchange protein
- Cl- channel
- PEST protein
- CD antigen
- solute carrier family 4 (SLC4, SLC4A)
- glycoprotein
- plasma membrane protein
References
- ↑ Alperts et al Molecular Biology of the Cell, Garland Publishing, New York, NY 1989 pg 289-291
- ↑ Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
- ↑ UniProt http://www.uniprot.org/uniprot/P02730.html
- ↑ Wikipedia; Note: Band 3 entry http://en.wikipedia.org/wiki/Band_3
- ↑ BGMUT; Note: Blood group antigen gene mutation database http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=diego
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC4A1
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/slc4a1/
- ↑ 8.0 8.1 Loinc
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6521
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6521
- OMIM: https://mirror.omim.org/entry/109270
- OMIM: https://mirror.omim.org/entry/110500
- OMIM: https://mirror.omim.org/entry/112010
- OMIM: https://mirror.omim.org/entry/112050
- OMIM: https://mirror.omim.org/entry/130600
- OMIM: https://mirror.omim.org/entry/179800
- OMIM: https://mirror.omim.org/entry/601550
- OMIM: https://mirror.omim.org/entry/601551
- OMIM: https://mirror.omim.org/entry/611590
- UniProt: http://www.uniprot.org/uniprot/P02730.html