A-kinase anchor protein 2; AKAP-2; AKAP-KL; protein kinase A-anchoring protein 2; PRKA2 (AKAP2, KIAA0920, PRKA2)

Function

• binds to regulatory subunit (RII) of protein kinase A may be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify & focus diffuse, trans-cellular signals carried by cAMP (putative)

Structure

• the RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer

Alternative splicing

named isoforms=5

More general terms

• A-kinase anchor protein
• phosphoprotein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11217
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=445815
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11217
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:445815
• OMIM: https://mirror.omim.org/entry/604582
• UniProt: http://www.uniprot.org/uniprot/Q9Y2D5.html