scavenger receptor class B member 1 (SRB1, CD36 antigen-like 1, CD36 & LIMP2 analogous 1, CLA-1, collagen type I receptor - thrombospondin receptor-like 1, SCARB1, CD36L1, CLA1, CLA2)

Function

• probable HDL receptor
• receptor for phospholipids, cholesterol ester, lipoproteins, phosphatidylserine & apoptotic cells
• facilitates the flux of free & esterified cholesterol between cell surface & HDL & to a lesser extent, apoB-containing lipopoteins
• involved in the phagocytosis of apoptotic cells, via phosphatidylserine binding
• C-terminal region binds to PDZK1 (putative)

Structure

• N-glycosylated
• belongs to the CD36 family

Compartment

• cell membrane
• predominantly localized to aveolae

Alternative splicing

named isoforms=4

Expression

• widely expressed

Pathology

• receptor for hepatitis C virus glycoprotein E2
• role in HCV attachment &/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer
• variant in SCARB1 raises HDL cholesterol & increases risk of coronary heart disease

Polymorphism

• the Ser-2 variant is associated with higher plasma triglyceride concentration in subjects with heterozygous familial hypercholesterolemia

More general terms

• scavenger receptor
• glycoprotein
• transmembrane 2 protein

Additional terms

• CD36; platelet glycoprotein 4; platelet glycoprotein IV; GPIV; glycoprotein IIIb; GPIIIB; leukocyte differentiation antigen CD36; PAS IV; PAS-4; platelet collagen receptor; fatty acid translocase; FAT; Thrombospondin receptor (GP3B, GP4)

Database

• OMIM: https://mirror.omim.org/entry/601040
• UniProt: http://www.uniprot.org/uniprot/Q8WTV0.html