canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; multidrug resistance-associated protein 2; canalicular multidrug resistance protein (ABCC2, CMOAT, CMOAT1, CMRP, MRP2)

Function

• mediates hepatobiliary excretion of numerous organic anions
• may function as a cellular cisplatin transporter

Structure

• belongs to the ABC transporter family, conjugate transporter (TC 3.A.1.208) subfamily
• contains 2 ABC transmembrane type-1 domains; residues 322-605 & 979-1264
• contains 2 ABC transporter domains; residues 637-861 & 1300-1534

Compartment

membrane

Expression

• found on the apical membrane of polarized cells in liver, kidney & intestine
• the highest expression is found in liver

Pathology

• defects in ABCC2 are the cause of Dubin-Johnson syndrome

More general terms

• transmembrane 17 protein
• ATP-binding cassette sub-family C (ABC transporter-C, ABCC)
• phosphoprotein
• glycoprotein

Additional terms

• chronic idiopathic jaundice (Dubin-Johnson syndrome)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1244
• OMIM: https://mirror.omim.org/entry/237500
• OMIM: https://mirror.omim.org/entry/601107
• UniProt: http://www.uniprot.org/uniprot/Q92887.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1244