chloride anion exchanger; down-regulated in adenoma; protein DRA; solute carrier family 26 member 3 (SLC26A3, DRA)

Function

• chloride/bicarbonate exchanger
• possible sulfate transporter
• involved in absorption in the colon
• helps mediate electrolyte & fluid absorption
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with PDZK1

Structure

• belongs to the SLC26A/sulP transporter (TC 2.A.53) family
• contains 1 STAS domain

Compartment

membrane (probable)

Expression

• intestinal epithlelium

Pathology

• expression is significantly decreased in
  • colorectal adenoma
  • adenocarcinoma of the colon
• defects in SLC26A3 are the cause of congenital chloride diarrhea

More general terms

• solute carrier family 25 (SLC25, SLC25A)
• transmembrane 14 protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P40879.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1811
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1811
• OMIM: https://mirror.omim.org/entry/126650
• OMIM: https://mirror.omim.org/entry/214700