CD80, antigen-presenting cell B7-1, B-lymphocyte activation antigen B7-1, or BB1

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Function

immunoglobulin-like molecule on the surface of antigen-presenting cells
role in autoimmune, humoral & transplant responses
co-regulates T cell activation with CD86
ligand for
- CD28 on T-cells; interaction of CD28 is necessary in addition to stimulation of the T-cell receptor for production of IL-2 in quiescent T-cells
- CD152

Expression

More general terms

References

↑ Pawson T. Protein modules and signalling networks. Nature. 1995 Feb 16;373(6515):573-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=941
↑ http://www.pathologyoutlines.com/cdmarkers.html 20 May 2003
↑ Protein Reviews on the Web http://mpr.nci.nih.gov/prow/guide/642335762_g.htm
↑ Uniprot http://www.uniprot.org/uniprot/P33681.html

Database

UniProt: http://www.uniprot.org/uniprot/P33681.html
OMIM: https://mirror.omim.org/entry/112203
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=941

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