T-cell receptor-associated transmembrane adapter 1 (T-cell receptor-interacting molecule, TRIM, pp29/30, TRAT, TCRIM, HSPC062)

Function

• stabilizes TCR (T-cell antigen receptor)/CD3 complex at surface of T-cells
• interacts with CD3Z
• when phosphorylated, interacts with PIK3R1
• phosphorylated on Tyr by LCK or FYN upon TCR activation

Structure

• homodimer; disulfide-linked

Compartment

cell membrane

Expression

• expressed in thymus > spleen, lymph node, peripheral blood lymphocytes
• expressed in T-cells & NK cells, but not B-cells

More general terms

• phosphoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/604962
• UniProt: http://www.uniprot.org/uniprot/Q6PIZ9.html