cytoplasmic FMR1-interacting protein 1 (specifically Rac1-associated protein 1, Sra-1, p140sra-1, CYFIP1, KIAA0068)

Function

• role in formation of membrane ruffles & lamellipodia protrusions & in axon outgrowth
• binds to F-actin but not to RNA
• interacts with the active GTP-bound form of RAC1
• interacts with FMR1/FMRP but does not bind to related proteins FXR1 or FXR2
• component of the WAVE2 complex
• interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2, necessary for DPYSL2-induced axon outgrowth

Structure

• belongs to the CYFIP family

Compartment

• cytoplasm, perinuclear region
• cell projection, lamellipodium, ruffle
• synaptosome
• highly expressed in the perinuclear region
• enriched in synaptosomes, membrane ruffles & at the tips of lamellipodia

Alternative splicing

named isoforms=3

More general terms

• cytoskeletal protein

Component of

• WAVE2 complex

Database

• OMIM: https://mirror.omim.org/entry/606322
• UniProt: http://www.uniprot.org/uniprot/Q7L576.html