partitioning defective 6 homolog gamma (PAR-6 gamma, PAR6D, PARD6G, PAR6G)

Function

• adapter protein involved in asymmetrical cell division & cell polarization processes
• role in formation of epithelial tight junctions (putative)
• PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins
• interacts with PARD3 (putative)
• interacts with GTP-bound forms of CDC42, ARHQ/TC10 & RAC1
  • pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
• interacts with the N-terminal part of PRKCI & PRKCZ

Compartment

cytoplasm

Expression

• widely expressed
• higher expression in fetal & adult kidney

More general terms

• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BYG4.html