dedicator of cytokinesis protein 7 (DOCK7, KIAA1771)

Function

• guanine nucleotide exchange factor (GEF) for Rac1 & Rac3
  • interacts with nucleotide-free RAC1 & RAC3
• no GEF activity for CDC42
• required for STMN1 'Ser-15' phosphorylation during axon formation & consequently for neuronal polarization
• interacts with TSC1

Structure

• the DHR-2 domain mediates GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 domain
• contains 1 DHR-2 domain

Compartment

• cell projection, axon.
• enriched in the developing axons of hippocampal neurons

Alternative splicing

named isoforms=6

Expression

widely expressed

More general terms

• dedicator of cytokinesis protein (DOCK)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85440
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85440
• UniProt: http://www.uniprot.org/uniprot/Q96N67.html