Cdc42 effector protein 3; binder of Rho GTPases 2; MSE55-related Cdc42-binding protein (CDC42EP3 BORG2 CEP3)

Function

• organization of the actin cytoskeleton
• induces actin filament assembly leading to cell shape changes
• induces pseudopodia formation in fibroblasts.
• may act downstream of CDC42
• interacts with RHOQ & CDC42 (GTP-dependent)
• interacts with SEPT7

Structure

• belongs to the BORG/CEP family
• contains 1 CRIB domain

Compartment

cytoplasm, cytoskeleton, membrane

Expression

• expressed in heart, weakly in brain

More general terms

• Cdc42 effector protein; binder of Rho GTPases

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10602
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10602
• OMIM: https://mirror.omim.org/entry/606133
• UniProt: http://www.uniprot.org/uniprot/Q9UKI2.html