Rho GTPase-activating protein 33; Rho-type GTPase-activating protein 33; Tc10/CDC42 GTPase-activating protein; sorting nexin-26 (ARHGAP33, SNX26, TCGAP)

Function

• may be involved in several stages of intracellular trafficking
• could play an important role in the regulation of glucose transport by insulin
• may act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport
• specifically interacts with CDC42 & RHOQ/TC10 through its Rho-GAP domain (putative)

Structure

• belongs to the PX domain-containing GAP family
• contains 1 PX (phox homology) domain
• contains 1 Rho-GAP domain
• contains 1 SH3 domain

Alternative splicing

named isoforms=4

More general terms

• sorting nexin
• rho GTPase-activating protein (rho-GAP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=115703
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:115703
• UniProt: http://www.uniprot.org/uniprot/O14559.html