Cdc42 effector protein 2; binder of Rho GTPases 1 (CDC42EP2, BORG1, CEP2)

Function

• organization of actin cytoskeleton
  • cell shape changes
  • pseudopodia formation in fibroblasts
• act downstream of CDC42
• interaction with RHOQ & CDC42 (GRP-dependent)
• interacts with SEPT7

Structure

• CRIB domain mediates interaction with CDC42
• belongs to the BORG/CEP family
• contains 1 CRIB domain

Compartment

cytoplasmic & membrane-associated

Expression

• highly expressed in heart
• weakly expressed in pancreas & liver

More general terms

• Cdc42 effector protein; binder of Rho GTPases
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10435
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10435
• OMIM: https://mirror.omim.org/entry/606132
• UniProt: http://www.uniprot.org/uniprot/O14613.html