Cdc42 effector protein 1; binder of Rho GTPases 5; serum protein MSE55 (CDC42EP1, BORG5, CEP1, MSE55)

Function

• probably involved in organization of the actin cytoskeleton
• induces membrane extensions in fibroblasts
• interacts with RHOQ & CDC42 (GTP-dependent)

Structure

• the CRIB domain mediates interaction with CDC42
• belongs to the BORG/CEP family
• contains 1 CRIB domain

Compartment

• endomembrane system; peripheral membrane protein
• cytoplasm, cytoskeleton

Alternative splicing

named isoforms=2

Expression

endothelial & bone marrow stromal cells

More general terms

• plasma protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11135
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11135
• OMIM: https://mirror.omim.org/entry/606084
• UniProt: http://www.uniprot.org/uniprot/Q00587.html