dedicator of cytokinesis protein 9; Cdc42 guanine nucleotide exchange factor zizimin-1 (DOCK9, KIAA1058)

Function

• guanine nucleotide-exchange factor (GEF)
• activates CDC42 by exchanging bound GDP for free GTP
• overexpression induces filopodia formation
• interacts preferentially with nucleotide-depleted CDC42

Structure

• the DHR-2 domain is necessary & sufficient for the GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 domain
• contains 1 DHR-2 domain
• contains 1 PH domain

Compartment

endomembrane system (probable)

Alternative splicing

named isoforms=4

Expression

• expressed in heart, placenta > kidney, brain, lung, skeletal muscle

Notes

• 'Zizim' means 'spike' in Hebrew

More general terms

• dedicator of cytokinesis protein (DOCK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23348
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23348
• OMIM: https://mirror.omim.org/entry/607325
• UniProt: http://www.uniprot.org/uniprot/Q9BZ29.html