Cdc42 effector protein 4; binder of Rho GTPases 4 (CDC42EP4, BORG4, CEP4)

Function

• organization of the actin cytoskeleton
• induces actin filament assembly leading to cell shape changes
• induces pseudopodia formation, when overexpressed in fibroblasts
• may act downstream of CDC42
• interacts with CDC42 & RHOQ (GTP-dependent)

Structure

• belongs to the BORG/CEP family
• contains 1 CRIB domain

Compartment

• endomembrane system; peripheral membrane
• cytoplasm, cytoskeleton

Expression

• not detected in adult tissues
• may be expressed only in fetal or embryonic tissues

More general terms

• Cdc42 effector protein; binder of Rho GTPases
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23580
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23580
• OMIM: https://mirror.omim.org/entry/605468
• UniProt: http://www.uniprot.org/uniprot/Q9H3Q1.html