Cdc42 effector protein 5; binder of Rho GTPases 3 (CDC42EP5, BORG3, CEP5)

Function

• organization of the actin cytoskeleton
  • may act downstream of CDC42 to induce actin filament
• induces pseudopodia formation in fibroblasts
• inhibits MAPK8 independently of CDC42 binding
• controls septin organization, this effect negatively regulated by CDC42
• interacts with CDC42, GTP-dependent manner
• interacts with SEPT7

Structure

• CRIB domain mediates interaction with CDC42
• belongs to the BORG/CEP family
• contains 1 CRIB domain

Compartment

• endomembrane system, peripheral membrane (putative)
• cytoplasm, cytoskeleton

More general terms

• Cdc42 effector protein; binder of Rho GTPases

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=148170
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:148170
• OMIM: https://mirror.omim.org/entry/609171
• UniProt: http://www.uniprot.org/uniprot/Q6NZY7.html