CD2-associated protein (Cas ligand with multiple SH3 domains, adapter protein CMS, CD2AP)

Function

• adapter protein between membrane proteins & actin cytoskeleton
• role in receptor clustering & cytoskeletal polarity in junction between T-cell & antigen-presenting cell
• may anchor podocyte slit diaphragm to the actin cytoskeleton in renal glomerulus
• interacts through its second SH3 domain with phosphorylated CBL C-terminus
• interacts with BCAR1/p130Cas SH3 domain
• interacts with F-actin, CD2, PKD2, NPHS1 & NPHS2
• interacts with FAM125A
• phosphorylated on tyrosine residues, probably by c-Abl, Fyn & c-Src

Structure

• homodimer, mediated by coiled coil domain
• contains 3 SH3 domains
• Pro-rich domain may mediate binding to SH3 domains

Compartment

• cytoplasm
• colocalizes with F-actin & BCAR1/p130Cas in membrane ruffles
• located at podocyte slit diaphragm between podocyte foot processes

Expression

widely expressed in fetal and adult tissues

Pathology

• defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis 3

More general terms

• phosphoprotein
• cytoskeletal protein

Database

• OMIM: https://mirror.omim.org/entry/604241
• OMIM: https://mirror.omim.org/entry/607832
• UniProt: http://www.uniprot.org/uniprot/Q9Y5K6.html