calcium/calmodulin-dependent protein kinase II beta (CAMK2B, CAMKB)

Function

• one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex
• interacts with SYNGAP1 (putative)
• interacts with MPDZ
• autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. CaMK subfamily
• contains 1 protein kinase domain

Alternative splicing

• named isoforms=7
• variable region of the CAMK2B protein is encoded by
• at least 7 exons (V1 to V7)
• alternative splicing within this region gives rise to CAMK2B isoforms

Expression

• widely expressed
• expressed in adult & fetal brain
• expression slightly lower in fetal brain

More general terms

• protein subunit
• serine/threonine kinase
• phosphoprotein
• calmodulin binding protein

Component of

• calcium/calmodulin dependent protein kinase 2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:816
• OMIM: https://mirror.omim.org/entry/607707
• UniProt: http://www.uniprot.org/uniprot/Q13554.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=816