claudin-5; transmembrane protein deleted in VCFS; TMDVCF (CLDN5 AWAL TMVCF)

Function

• plays a major role in tight junction-specific obliteration of the intercellular space (putative)
• directly interacts with TJP1/ZO-1, TJP2/ZO-2 & TJP3/ZO-3
• interacts with MPDZ (putative)

Structure

• belongs to the claudin family

Compartment

• cell junction, tight junction
• cell membrane; multi-pass membrane protein

More general terms

• claudin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7122
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7122
• OMIM: https://mirror.omim.org/entry/602101
• UniProt: http://www.uniprot.org/uniprot/O00501.html