calcium/calmodulin-dependent protein kinase II alpha (CAMK2A, CAMKA, KIAA0968)

Function

• one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex
• interacts with BAALC, MPDZ, SYN1 & SYNGAP1 (putative)
• autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state (putative)

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
• contains 1 protein kinase domain

Compartment

• cell junction, synapse
• presynaptic cell membrane (putative)
• postsynaptic lipid rafts (putative)

Alternative splicing

named isoforms=2

More general terms

• protein subunit
• serine/threonine kinase
• phosphoprotein
• calmodulin binding protein

Component of

• calcium/calmodulin dependent protein kinase 2

Database

• OMIM: https://mirror.omim.org/entry/114078
• UniProt: http://www.uniprot.org/uniprot/Q9UQM7.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=815