brain & acute leukemia cytoplasmic protein (BAALC)

Function

• synaptic role at the postsynaptic lipid rafts via interacting with CAMK2A (putative)

Structure

• palmitoylation & myristoylation target the protein to the lipid rafts

Compartment

cytoplasm, membrane, postsynaptic lipid rafts

Alternative splicing

named isoforms=6

Expression

• expressed by neural & hematopoietic cells
• expressed in early progenitor cells, but not in mature hematopoietic cells
• isoforms 2 & 6 are expressed in brain
• isoform 2 shows a low expression in neuroectoderm-derived tissues, i.e. adrenal gland

Pathology

• expressed in most immature type of blasts in acute leukemia

More general terms

• other protein

Database

• OMIM: https://mirror.omim.org/entry/606602
• UniProt: http://www.uniprot.org/uniprot/Q8WXS3.html