Junctional adhesion molecule-like (Dendritic cell-specific protein CREA7-1, Adhesion molecule interacting with CXADR antigen 1) (AMICA1 JAML UNQ722/PRO1387)

Function

• may function in transmigration of leukocytes through epithelial & endothelial tissues
• at plasma membrane of polymorphonuclear leukocytes, mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells
• enhances myeloid leukemia cell adhesion to endothelial cells
• interacts with CXADR

Structure

• belongs to the immunoglobulin superfamily
• contains 2 Ig-like V-type domains (immunoglobulin-like) Ig-like V-type domain 2 mediates interaction with CXADR

Compartment

• cell junction
• localized at the plasma membrane in areas of cell-cell contacts & at the cell surface of PMN

Alternative splicing

named isoforms=3

Expression

• expression is restricted to the hematopoietic tissues & liver
• expressed in fetal liver, spleen & thymus
• up-regulated upon retinoic acid, Me2SO & PMA treatment in differentiating myeloid leukemia cells

More general terms

• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86YT9.html