metalloproteinase inhibitor 1; Tissue inhibitor of metalloproteinases; TIMP-1; erythroid-potentiating activity; EPA; fibroblast collagenase inhibitor; collagenase inhibitor (TIMP1, CLGI)

Function

• complexes with metalloproteinases (such as collagenases) & irreversibly inactivates them
• also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating growth & differentiation of only human & murine erythroid progenitors
• known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 & MMP-16
• does not act on MMP-14

Structure

• belongs to the protease inhibitor I35 (TIMP) family
• contains 1 NTR domain
• activity of TIMP1 is dependent on the presence of disulfide bonds

Compartment

secreted

Laboratory

• tissue inhibitor of metalloproteinases 1 in serum/plasma

More general terms

• inhibitor of metalloproteinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7076
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7076
• OMIM: https://mirror.omim.org/entry/305370
• UniProt: http://www.uniprot.org/uniprot/P01033.html