matrix metalloproteinase-7; matrixin-7; matrin; urine metalloproteinase; pump-1 protease; matrylisin (MMP7, MPSL1, PUMP1)

Function

• degrades casein, gelatins of types 1, 3, 4, & 5, & fibronectin
• activates procollagenase cleavage of 14-Ala-|-Leu-15 & 16-Tyr-|-Leu-17 in B chain of insulin
• no action on collagen types 1, 2, 4, 5
• can cleave elastin
• cleaves gelatin chain alpha-2(I) > alpha-1(I)

Cofactor:

• binds 2 Ca+2 per subunit
• binds 2 Zn+2 per subunit

Structure

• conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme; dissociation of the Cys from the Zn+2 upon the activation-peptide release activates the enzyme
• belongs to the peptidase M10A family

More general terms

• matrixin elastase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4316
• UniProt: http://www.uniprot.org/uniprot/P09237.html
• OMIM: https://mirror.omim.org/entry/178990
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4316