matrix metalloproteinase-7 (matrixin-7, matrin, urine metalloproteinase, pump-1 protease, matrylisin, MMP7, MPSL1, PUMP1)
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Function
- degrades casein, gelatins of types 1, 3, 4, & 5, & fibronectin
- activates procollagenase cleavage of 14-Ala-|-Leu-15 & 16-Tyr-|-Leu-17 in B chain of insulin
- no action on collagen types 1, 2, 4, 5
- cleaves gelatin chain alpha-2(I) > alpha-1(I)
Structure
- conserved Cys present in the cysteine-switch motif binds the catalytic Zn+2, thus inhibiting the enzyme; dissociation of the Cys from the Zn+2 upon the activation-peptide release activates the enzyme
- belongs to the peptidase M10A family