metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3; TIMP-3; protein MIG-5 (TIMP3)
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Function
- complexes with metalloproteinases (such as collagenases) & irreversibly inactivates them
- may form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 & MMP-15
Structure
- belongs to the protease inhibitor I35 (TIMP) family
- contains 1 NTR domain
Compartment
Pathology
- defects in TIMP3 are the cause of Sorsby fundus dystrophy
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P35625.html
- ↑ Mutations of the TIMP3 gene; Note: retina
- ↑ International's scientific newsletter http://www.retina-international.com/sci-news/timpmut.htm
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=TIMP3
- ↑ Pavloff N et al A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. J Biol Chem 267:17321 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1512267
- ↑ Kishnani NS et al Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix. Matrix Biol. 1995 Feb;14(6):479-88. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7795886
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7078