metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4 (TIMP4)
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Function
- complexes with metalloproteinases (such as collagenases) & irreversibly inactivates them
- known to act on MMP-1, MMP-2, MMP-3, MMP-7 & MMP-9
Structure
- belongs to the protease inhibitor I35 (TIMP) family
- contains 1 NTR domain
Compartment
Expression
- abundant in heart
- low levels in many other tissues