metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4 (TIMP4)

Function

• complexes with metalloproteinases (such as collagenases) & irreversibly inactivates them
• known to act on MMP-1, MMP-2, MMP-3, MMP-7 & MMP-9

Structure

• belongs to the protease inhibitor I35 (TIMP) family
• contains 1 NTR domain

Compartment

secreted

Expression

• abundant in heart
• low levels in many other tissues

Pathology

• biomarker of brain aging (positive correlation)*

* higher plasma levels associated with faster brain aging

More general terms

• inhibitor of metalloproteinase

Database

• UniProt: http://www.uniprot.org/uniprot/Q99727.html
• OMIM: https://mirror.omim.org/entry/601915
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7079