energy-dependent nucleolar silencing complex (eNoSC complex)

Function

• mediates silencing of rDNA in response to intracellular energy status
• acts by recruiting histone-modifying enzymes
• able to sense the energy status of cell
  • upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 & the formation of silent chromatin in the rDNA

Structure

• subunits include: SIRT1, SUV39H1 & RRP8

More general terms

• molecular complex