ribosomal RNA-processing protein 8; cerebral protein 1; nucleomethylin (RRP8, KIAA0409, NML, hucep-1)

Function

• essential component of the eNoSC complex
• in the complex, RRP8 binds to H3K9me2 & probably acts as a methyltransferase
• its substrates are unknown

Structure

• belongs to the methyltransferase superfamily, RRP8 family

Compartment

• nucleus, nucleolus
• localizes at rDNA locus

More general terms

• methyltransferase
• phosphoprotein
• nuclear protein

Component of

• energy-dependent nucleolar silencing complex (eNoSC complex)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23378
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23378
• UniProt: http://www.uniprot.org/uniprot/O43159.html