red wine
Introduction
Red wine may have especially potent cardioprotective effect against coronary artery disease. Resveratrol is thought to be a major beneficial component of red wine.
Polyphenols in ethanol-free extracts of red wine diminished synthesis of endothelin-1 by cultured bovine endothelial cells. Red grape juice had a similar, but less potent effect. White & rose wines did not have this effect. The reduction in endothelin-1 was not mediated by antioxidant properties of the red-grape polyphenols.
Lower all cause mortality in men 23-37%[2]
Only alcoholic beverage associated with diminished risk of ischemic stroke. RR = 0.5 for > 10 g/day[3]
red wine 1-7 servings per week may diminish risk of new-onset atrial fibrillation[5]
red wine (150 mL daily) associated with increased HDL cholesterol (2.0 mg/dL), serum apolipoprotein<a>1 (0.03 g/L) & cholesterol/HDL ratio (0.27), relative to mineral water
Benefit of red wine may be due to other components in addition to resveratrol.[4]
More general terms
Additional terms
References
- ↑ Journal Watch 22(3):21, 2002 Corder et al, Nature 414: 863, 2001
- ↑ 2.0 2.1 Netscape (09/20/04) cites American Journal of Clinical Nutrition
- ↑ 3.0 3.1 Journal Watch 25(3):24, 2005 Mukamal KJ, Ascherio A, Mittleman MA, Conigrave KM, Camargo CA Jr, Kawachi I, Stampfer MJ, Willett WC, Rimm EB. Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. Ann Intern Med. 2005 Jan 4;142(1):11-9. Summary for patients in: Ann Intern Med. 2005 Jan 4;142(1):I24. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15630105
- ↑ 4.0 4.1 Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006 Nov;20(13):2313-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17077308
- ↑ 5.0 5.1 Stiles S New-AF Risk May Not Rise With Light Drinking, May Fall With Wine. Medscape - Aug 06, 2021 https://www.medscape.com/viewarticle/956211
Tu SJ, Gallagher C, Elliott AD et al Risk Thresholds for Total and Beverage-Specific Alcohol Consumption and Incident Atrial Fibrillation. JACC: Clinical Electrophysiology. Available online 27 July 2021 PMID: https://www.ncbi.nlm.nih.gov/pubmed/34330672 https://www.sciencedirect.com/science/article/abs/pii/S2405500X21005247 - ↑ Haas EA, Saad MJA, Santos A et al A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition. Am J Clin Nutr. 2022 Dec 19;116(6):1515-1529. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36205549 PMCID: PMC9761755 Free PMC article