forkhead box protein O3A; forkhead in rhabdomyosarcoma-like 1 (FKHRL1, FOXO3A, FOXO3)

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Function

Structure

contains 1 fork-head DNA-binding domain

Compartment

Expression

ubiquitous

Pathology

Polymorphism

More general terms

References

  1. Brunet et al. Cell 96:857-68, 1999
  2. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2309
  3. UniProt http://www.uniprot.org/uniprot/O43524.html
  4. 4.0 4.1 Brunet A et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004, 303:2011-2015 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14976264
  5. Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/AF6q21ID125.html
  6. 6.0 6.1 Li Y et al Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet. 2009 Dec 15;18(24):4897-904. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19793722
  7. 7.0 7.1 Calnan DR et al Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul 21. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22820736
  8. 8.0 8.1 8.2 8.3 Xie Q et al Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep. 2012 Apr;13(4):371-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22402663

Database