TSC22 domain family protein 3; glucocorticoid-induced leucine zipper protein; delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive peptide; protein DIP; hDIP; TSC-22-like protein; TSC-22R (TSC22D3, DSIPI, GILZ)
Jump to navigation
Jump to search
Function
- protects T-cells from IL2 deprivation-induced apoptosis through inhibition of FOXO3A transcriptional activity that leads to down-regulation of pro-apoptotic factor BCL2L11
- in macrophages, plays a role in the anti-inflammatory & immunosuppressive effects of glucocorticoids & IL10
- in T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation
- in vitro, suppresses AP1 & NFKB1 DNA-binding activities
- interacts with AP1 & NFKB1
Structure
- belongs to the TSC-22/Dip/Bun family
- can form homodimers, however likely to function as monomer
- leucine-zipper is involved in homodimerization
Alternative splicing
named isoforms=3
Expression
- expressed in brain, lung, spleen, skeletal muscle
- lower levels detected in heart, kidney
- not detected in pancreas
- in non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineag
- expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B-cells & T-cells, monocytes & granulocytes
- induced by glucocorticoids in lymphoid cells & upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells
- transiently induced by IL2 deprivation in T-cells
Pathology
- down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, including tuberculosis & in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells