sirtuin (silent mating type information regulation 2 homolog)

Introduction

A family of proteins found in all kingdoms of life. Mammals have 7 sirtuins.

Function

• deacetylation
  • sirtuins deacetylate & activate acetyl CoA synthetase
• mono ADP ribosylation
• coupled to degradation of NAD+
• cell survival, fat metabolism, insulin secretion
• may regulate stress-response
• small molecular activators of sirtuins promote survival of eukaryotic cells
• these small molecular activators include polyphenols:
  • resveratrol
  • fisetin
  • isoliquiritigenin
  • piceatannol
  • butein

NAD+ + acetylprotein
        <-->
nicotinamide + O-acetyl-ADP-ribose + protein

More general terms

• histone deacetylase

More specific terms

• sirtuin 1; NAD-dependent deacetylase sirtuin 1; silent mating type information regulation 2 homolog 1 (SIRT1)
• sirtuin 2; NAD-dependent deacetylase sirtuin 2; silent mating type information regulation 2 homolog 2 (SIRT2)
• sirtuin 3 (NAD-dependent deacetylase sirtuin, silent mating type information regulation 2 homolog 3 mitochondrial, SIRT3)
• sirtuin 4 (NAD-dependent deacetylase sirtuin 4, silent mating type information regulation 2 homolog 4, SIRT4)
• sirtuin 5 (NAD-dependent deacetylase sirtuin 5, silent mating type information regulation 2 homolog 5, SIRT5)
• sirtuin 6 (mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent deacetylase sirtuin, silent mating type information regulation 2 homolog) 6 (SIRT6)
• sirtuin 7 (NAD-dependent deacetylase sirtuin 7, silent mating type information regulation 2 homolog 7, SIRT7)

Additional terms

• sirtinol