sirtuin 7 (NAD-dependent deacetylase sirtuin 7, silent mating type information regulation 2 homolog 7, SIRT7)

Function

• probable NAD-dependent deacetylase

NAD+ + an acetylprotein
        <-->
nicotinamide + O-acetyl-ADP-ribose + a protein

Cofactor: binds 1 Zn+2 per subunit

Structure

• belongs to the sirtuin family
• contains 1 deacetylase sirtuin-type domain

Compartment

cytoplasm, located under nuclear membrane

Alternative splicing

named isoforms=2

Pathology

• overexpressed in human thyroid carcinoma cell lines & tissues, but not in adenomas

More general terms

• sirtuin (silent mating type information regulation 2 homolog)

Database

• OMIM: https://mirror.omim.org/entry/606212
• UniProt: http://www.uniprot.org/uniprot/Q9NRC8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51547