sirtuin 3 (NAD-dependent deacetylase sirtuin, silent mating type information regulation 2 homolog 3 mitochondrial, SIRT3)
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Function
- NAD-dependent deacetylase
- despite some ability to deacetylate histones in vitro, unlikely to do so in vivo
- may activate thermogenesis in brown adipocytes[2]
- linked to circadian rhythms[3]
- may activate mitochondrial metabolism during fasting
NAD+ + an acetylprotein
<-->
nicotinamide + O-acetyl-ADP-ribose + a protein
Cofactor: binds 1 Zn+2 per subunit
Structure
- processed by mitochondrial processing peptidase (MPP) to give a 28 kD product, processing likey essential for enzymatic activity
- belongs to the sirtuin family
- contains 1 deacetylase sirtuin-type domain
Compartment
Expression
widely expressed
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NTG7.html
- ↑ 2.0 2.1 Shi T, Wang F, Stieren E, Tong Q. SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem. 2005 Apr 8;280(14):13560-7. Epub 2005 Jan 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15653680
- ↑ 3.0 3.1 Peek CB, Affinati AH, Ramsey KM et al Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice. Science. 2013 Sep 19. [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/24051248