sirtuin 6 (mono-ADP-ribosyltransferase sirtuin-6, NAD-dependent deacetylase sirtuin, silent mating type information regulation 2 homolog) 6 (SIRT6)

Function

• auto ADP-ribosylated

NADP+ + protein-L-arginine
      <-->
nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

Cofactor: binds 1 Zn+2 per subunit

Structure

• belongs to the sirtuin family
• contains 1 deacetylase sirtuin-type domain

Compartment

nucleus (predominantly nuclear)

Alternative splicing

named isoforms=4

Expression

• widely expressed

More general terms

• sirtuin (silent mating type information regulation 2 homolog)
• mono ADP-ribosyltransferase

Database

• OMIM: https://mirror.omim.org/entry/606211
• UniProt: http://www.uniprot.org/uniprot/Q8N6T7.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51548