sirtuin 4 (NAD-dependent deacetylase sirtuin 4, silent mating type information regulation 2 homolog 4, SIRT4)

Function

• probable NAD-dependent deacetylase

NAD+ + an acetylprotein
        <-->
nicotinamide + O-acetyl-ADP-ribose + a protein

Cofactor: binds 1 Zn+2 per subunit

Structure

• belongs to the sirtuin family
• contains 1 deacetylase sirtuin-type domain

Expression

• widely expressed
• weakly expressed in leukocytes & fetal thymus

More general terms

• sirtuin (silent mating type information regulation 2 homolog)

Database

• OMIM: https://mirror.omim.org/entry/604482
• UniProt: http://www.uniprot.org/uniprot/Q9Y6E7.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23409