hairy/enhancer-of-split related with YRPW motif 2 (cardiovascular helix-loop-helix factor 1, hairy & enhancer of split-related protein 2, HESR-2, hairy-related transcription factor 2, HES-related repressor protein 2, protein gridlock homolog, HEY2, CHF1, GRL, HERP, HERP1, HRT2)
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Function
- participates in Notch signaling pathways
- role downstream of Notch signaling in vascular development (putative)
- roles in cardiovascular development & ventricular septation
- binds to the canonical E box sequence 5'-CACGTG-3'
- role as transcriptional repressor (putative)
Structure
- contains 1 basic helix-loop-helix (bHLH) domain
- contains 1 Orange domain
Compartment
nucleus (probable)
Expression
- induced by overexpression of constitutively active Notch intracellular domain
Pathology
- defects in HEY2 may be involved in atrioventricular septal defects