nicotinamide phosphoribosyltransferase (NAmPRTase, Nampt, pre-B cell-enhancing factor, pre-B-cell colony-enhancing actor 1, visfatin, NAMPT, PBEF, PBEF1)

Function

• catalyzes condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD
• rate limiting component in the mammalian NAD biosynthesis

Nicotinamide D-ribonucleotide + diphosphate
<-->
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in bone marrow, liver, muscle > heart, placenta, lung, kidney

Notes

• originally thought to be a cytokine acting on early B-lineage precursor cells, by enhancing the effect of IL-7 & SCF on pre-B-cell colony formation

More general terms

• phosphoribosyltransferase

Database

• OMIM: https://mirror.omim.org/entry/608764
• UniProt: http://www.uniprot.org/uniprot/P43490.html