radiation necrosis
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Introduction
Radiation necrosis in the brain can produce a clinical picture & result in CT or MRI imaging studies indistinguishable from recurrent high-grade tumor.
PET & SPECT scan may be useful for distinguishing the two. Theoretically, necrosis should show hypometabolism & tumor recurrence should show hypermetabolism. However, both radiation necrosis & tumor recurrence may both be present making interpretation of PET & SPECT scans difficult.
Management
- no adequate treatment
- anticoagulation has been reported to be of benefit
- experimental
- in mice, fluoroquinolone & an endotoxin-clearing protein (rBPI21) mitigate radiation-induced bone marrow aplasia & necrosis
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Guinan EC et al. Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med 2011 Nov 23; 3:110ra118 Not yet indeexed in PubMed http://stm.sciencemag.org/content/3/110/110ra118