oxprenolol (Coretal)

Laboratory

• oxprenolol in serum/plasma
• oxprenolol in urine

Mechanism of action

• inhibits beta-1 adrenergic receptors in the heart & vascular smooth muscle decreasing
  • heart rate
  • cardiac output
  • systolic blood pressure
  • diastolic blood pressure
• inhibits beta-2 adrenergic receptors in
  • bronchiole smooth muscle causing vasoconstriction
  • juxtaglomerular apparatus inhibiting production of renin, angiotensin II & aldosterone

More general terms

• beta adrenergic receptor antagonist (beta-blocker)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4631
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=71172